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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
Published on: August 14, 2018
Phylogenetic Analysis of Protein Family
Letian Song1, Sherry Wu2, Adrian Tsang3
1Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montreal, H4B 1R6, Quebec, Canada. letian.song@concordia.ca.
Abstract:
With the number of sequenced genomes increasing rapidly, it is impractical to perform functional and structural analyses on all individual proteins. Phylogenetic analysis employs a combination of molecular and statistical approaches to infer or estimate relationships among individuals. It provides a credible method to explore the relationship between sequence similarity and function of proteins belonging to the same family. This chapter describes a standardized framework of phylogenetic analysis to study large protein families. Bioinformatic approaches and online tools used in phylogenetic analyses are presented.
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