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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Stem Cell and Obesity: Current State and Future Perspective.

Moloud Payab1, Parisa Goodarzi2, Najmeh Foroughi Heravani3

  • 1Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Advances in Experimental Medicine and Biology
|June 8, 2018
PubMed
Summary

Cell-based therapies show promise for obesity management by targeting abnormal fat deposition. Further research into adipose-derived stromal cells could lead to effective clinical treatments for obesity and related metabolic disorders.

Keywords:
AdipocyteAdipose tissueAnimal modelsCell therapyMesenchymal stem/stromal cellsObesity

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Area of Science:

  • Biomedical Science
  • Regenerative Medicine
  • Metabolic Research

Background:

  • Obesity is a global health crisis characterized by excessive fat accumulation, increasing risks for type 2 diabetes, dyslipidemia, hypertension, cardiovascular diseases, and metabolic syndrome.
  • Current obesity treatments including lifestyle changes, medications, and surgery offer limited success, highlighting the need for novel therapeutic strategies.
  • Understanding adipose tissue biology, signaling pathways, and adipocyte development is crucial for developing innovative obesity management approaches.

Purpose of the Study:

  • To explore the potential of cell-based therapies as a novel strategy for obesity treatment.
  • To investigate the role of adipose-derived stromal cells in managing obesity and associated metabolic complications.
  • To review recent advancements in cell-based methods for obesity control.

Main Methods:

  • Review of preclinical studies utilizing cell-based approaches in obese mouse models.
  • Examination of various cell-based methods including stem cell administration, brown adipose tissue transplantation, cell lysates, and exosomes.
  • Analysis of key factors and signaling pathways involved in adipocyte development and function.

Main Results:

  • Cell-based therapies, including stem cells and exosomes, have demonstrated potential in preclinical models for managing obesity and related disorders.
  • These approaches target abnormal fat deposition and associated metabolic risk factors.
  • Successful preclinical outcomes provide a foundation for future clinical investigations.

Conclusions:

  • Cell-based therapy using adipose-derived stromal cells presents a promising avenue for addressing the limitations of current obesity treatments.
  • Further research and successful preclinical studies pave the way for potential clinical trials in cell-based obesity management.
  • This approach offers a novel strategy to control obesity and its related metabolic syndromes.