Related Experiment Video
Updated: Feb 9, 2026

Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica
Published on: July 9, 2015
At the heart of inter- and intracellular signaling: the intercalated disc
Heather R Manring1, Lisa E Dorn1, Aidan Ex-Willey1
1Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Abstract:
Proper cardiac function requires the synchronous mechanical and electrical coupling of individual cardiomyocytes. The intercalated disc (ID) mediates coupling of neighboring myocytes through intercellular signaling. Intercellular communication is highly regulated via intracellular signaling, and signaling pathways originating from the ID control cardiomyocyte remodeling and function. Herein, we present an overview of the inter- and intracellular signaling that occurs at and originates from the intercalated disc in normal physiology and pathophysiology. This review highlights the importance of the intercalated disc as an integrator of signaling events regulating homeostasis and stress responses in the heart and the center of several pathophysiological processes mediating the development of cardiomyopathies.
Related Concept Videos
Intracellular Signaling Cascades
Intracellular Signaling Affects Focal Adhesions
Some...
Yeast Signaling
Endocrine Signaling
What is Cell Signaling?
Anatomy of the Heart

