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Onabotulinumtoxin A (BOTOX®) for ProphylaCTIC Treatment of Pediatric Migraine: A Retrospective Longitudinal Analysis

Shalini Shah1, Michael-David Calderon1, Wei Der Wu1

  • 11 Department of Anesthesiology & Perioperative Care, University of California, Irvine, Orange, CA, USA.

Journal of Child Neurology
|June 8, 2018
PubMed

Insights

Onabotulinumtoxin A significantly reduced chronic migraine frequency, intensity, and duration in pediatric patients over a 5-year period. This study highlights its efficacy and safety for young individuals suffering from chronic migraine.

Area of Science:

  • Neurology
  • Pediatric Medicine
  • Pain Management

Background:

  • Limited longitudinal data exists on onabotulinumtoxin A for pediatric chronic migraine.
  • This study addresses the efficacy and safety gap in this population.

Purpose of the Study:

  • To evaluate the effectiveness of onabotulinumtoxin A as a prophylactic treatment for chronic migraine in children.
  • To assess the safety profile of onabotulinumtoxin A in pediatric patients.

Main Methods:

  • Retrospective evaluation of pediatric patients treated for chronic migraine.
  • Collected demographic data, and pre- and post-treatment migraine frequency, intensity, and duration.

Main Results:

  • Significant reduction in monthly headache frequency from 15.5 to 4 days (P < .0001).
  • Statistically significant decrease in migraine duration (P = .025) and intensity (P = .0063).
  • No serious adverse events were reported during the study period.

Conclusions:

  • Onabotulinumtoxin A demonstrated statistically significant improvement in chronic migraine metrics in pediatric patients.
  • The 5-year longitudinal data supports the efficacy and safety of onabotulinumtoxin A for this demographic.
Abstract

Keywords:
childrenchronic migrainemigraine prophylaxisonabotulinumtoxin Apediatric migraine

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