[Acute graft-versus-host disease: diagnosis and treatment]

Acute graft-versus-host disease (GVHD) is diagnosed by the presence of, at least, one of the skin, liver, and gut damage and the absence of a disease similar to it. Except upper gastrointestinal GVHD, acute GVHD is diagnosed on the basis of clinical findings. The diagnosis via biopsy does not necessarily coincide with the clinical diagnosis of acute GVHD. Although the systemic grade is categorized according to the organ stage, it does not accurately reflect the treatment response or prognosis. The identification of GVHD biomarker is currently being intensively investigated to supplement the insufficient risk stratification. Perhaps, the establishment of risk stratification that can accurately reflect the treatment response and prognosis may change the acute GVHD therapy into stratified therapy.