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Exposure to rotating magnetic fields alters morphine-induced behavioral responses in two strains of mice
Abstract:
An exposure for 60 min to a 0.5 Hz rotating magnetic field (1.5-90 G) significantly reduced the day-time analgesic and locomotory effects of morphine (10 mg/kg) in CF-1 and C-57BL strains of mice, respectively. Exposure to lower intensity 60 Hz magnetic fields (0.-1.0 G) had no effect on analgesia induced by morphine. The reduction in responsiveness to morphine after exposure to the greater intensity rotating field was not evident 24 hr later. No changes were seen in the latencies of basal thermal responses or levels of activity of saline-treated mice exposed to the magnetic stimuli.
Insights
High-intensity rotating magnetic fields significantly reduced morphine
Area of Science:
- Neuroscience
- Biophysics
Background:
- Morphine is a widely used analgesic.
- Magnetic field exposure is increasingly studied for biological effects.
Purpose of the Study:
- To investigate the effect of rotating magnetic fields on morphine's analgesic and locomotory effects.
Main Methods:
- Mice (CF-1 and C-57BL strains) were exposed to 0.5 Hz rotating magnetic fields (1.5-90 G) for 60 min.
- Morphine's effects (analgesia, locomotion) were assessed.
- Control groups received saline or were exposed to lower intensity 60 Hz fields.
Main Results:
- A 0.5 Hz rotating magnetic field (1.5-90 G) significantly reduced morphine's day-time analgesic and locomotory effects.
- Lower intensity 60 Hz magnetic fields (0.1-1.0 G) had no effect on morphine analgesia.
- Reduced responsiveness to morphine was not observed 24 hours post-exposure.
- No changes in basal thermal responses or activity levels were noted in saline-treated mice.
Conclusions:
- High-intensity rotating magnetic fields can modulate the efficacy of morphine.
- The observed effects are transient, not persisting 24 hours later.
- Magnetic field exposure does not alter baseline physiological responses in mice.