Differences in Clinical Features in Patients with Acute Coronary Syndrome and Stroke: Japanese Multicenter Registry
Ryo Naito1, Katsumi Miyauchi1, Shuko Nojiri2
1Department of Cardiovascular Medicine, Juntendo University School of Medicine, Japan.
Insights
Acute coronary syndrome (ACS) and ischemic stroke patients exhibit distinct clinical features. Understanding these differences, including gender-specific variations, is crucial for identifying high-risk populations and preventing atherothrombotic diseases.
Area of Science:
- Cardiovascular medicine
- Public health
- Epidemiology
Background:
- Coronary artery disease and cerebrovascular disease are leading causes of non-communicable diseases.
- Acute coronary syndrome (ACS) and ischemic stroke represent severe manifestations of these conditions.
- Identifying high-risk populations is essential for disease prevention.
Purpose of the Study:
- To investigate clinical feature differences between ACS and ischemic stroke patients.
- To examine gender-specific variations in patient characteristics.
- To analyze data from nationwide Japanese multicenter registries.
Main Methods:
- Analysis of datasets from the PACIFIC (ACS) and EVEREST (ischemic stroke) registries.
- Comparison of clinical features and background characteristics.
- Evaluation of a total of 6,878 patients.
Main Results:
- Significant differences in background characteristics were observed between ACS and stroke patients.
- ACS patients were generally younger, with higher BMI, more diabetes, dyslipidemia, and smoking history.
- Hypertension was more prevalent in stroke patients, with notable gender differences in prevalence.
- Gender analysis revealed similar characteristic differences between ACS and stroke in men, but not in women regarding hypertension.
Conclusions:
- Patient background characteristics significantly differ between ACS and ischemic stroke.
- Observed gender differences in clinical features warrant further investigation.
- These findings contribute to a better understanding of atherothrombotic disease populations.
Abstract:
Objective Coronary artery and cerebrovascular disease are the main causes of non-communicable diseases. In particular, acute coronary syndrome (ACS) and ischemic stroke are the most serious conditions of coronary artery disease and cerebrovascular disease, respectively. Therefore, it is important to prevent these conditions by identifying populations at high risk of these diseases. We sought to investigate the differences in the clinical features of patients with these atherothrombotic diseases in nationwide Japanese multicenter registries. Gender differences were also examined. Methods The dataset of the two nationwide multicenter registries for ACS [Prevention of AtherothrombotiC Incidents Following Ischemic Coronary (PACIFIC)] and ischemic stroke [Effective Vascular Event REduction after STroke (EVEREST)] was analyzed. Clinical features were examined and compared using datasets from the two registries. Results A total of 6,878 patients (PACIFIC: n=3,426, EVEREST: n=3,452) were evaluated. The patients' background characteristics were significantly different between the two populations. Patients with ACS tended to be younger, had a higher body mass index, had a greater prevalence of diabetes mellitus and dyslipidemia, were current smokers, and more often had a prior history of ischemia heart disease than patients with a stroke. Hypertension was more prevalent in patients with stroke than in those with ACS. The differences in patients' background characteristics between ACS and stroke in men were similar to those in the whole sample. However, the prevalence of hypertension in women was similar between the ACS and stroke groups, in contrast to the results from the whole sample. Conclusion Patients' background characteristics were significantly different between those with ACS and stroke. Gender differences were also observed.
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