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Updated: Feb 9, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Shan-Shan Zhou1,2, Jing-Peng Jin3, Ji-Qun Wang1,2
1The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun, 130021, China.
Insights
Circulating microRNAs (miRNAs) show promise as diagnostic biomarkers for cardiovascular diseases (CVD). Research highlights their potential as novel therapeutic targets to combat heart failure, myocardial infarction, and other CVDs.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Cardiovascular diseases (CVD) remain a primary global cause of death.
- Despite advances, novel diagnostic biomarkers and treatments for CVD are crucial.
- Circulating microRNAs (miRNAs) are emerging as potential biomarkers for CVD.
Purpose of the Study:
- To review the impact of various CVDs on circulating miRNA levels.
- To explore the therapeutic potential of miRNAs in cardiovascular disorders.
- To discuss challenges and recommendations for using miRNAs in CVD diagnosis.
Main Methods:
- Literature review of studies on CVD and circulating miRNAs.
- Analysis of miRNA expression changes in heart failure, myocardial infarction, arrhythmias, and pulmonary hypertension.
- Synthesis of current knowledge on miRNA-based diagnostics and therapeutics.
Main Results:
- Specific circulating miRNA profiles are altered in different CVDs.
- miRNAs demonstrate potential as non-invasive biomarkers for CVD detection.
- miRNAs offer promising targets for novel cardiovascular therapies.
Conclusions:
- Circulating miRNAs are valuable indicators for diagnosing and potentially treating cardiovascular diseases.
- Further research is needed to overcome challenges in miRNA-based clinical applications.
- miRNAs represent a significant advancement in cardiovascular medicine.
Abstract:
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this disease. Recently, there is increasing evidence that circulating miRNAs (miRNAs), i.e. endogenous, stable, single-stranded, short, non-coding RNAs, can be used as diagnostic biomarkers for CVD. Furthermore, miRNAs represent potential novel therapeutic targets for several cardiovascular disorders. In this review we provides an overview of the effects of several CVD; including heart failure, acute myocardial infarction, arrhythmias and pulmonary hypertension; on levels of circulating miRNAs. In addition, the use of miRNA as therapeutic targets is also discussed, as well as challenges and recommendations in their use in the diagnosis of CVD.
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