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Updated: Feb 9, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
1Department of Preclinical and Translational Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Abstract:
The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in the context of drug development. Topics covered include an overview of antibody development, PK characteristics, and the application of antibody PK/pharmacodynamics (PD) in research and development decision-making. We also discuss the general considerations for planning a nonclinical PK program and describe the types of PK studies that should be performed during early development of monoclonal antibodies.
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