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[Microbiota and malnutrition: an overview].

Julie Mareschal1, Jacques Schrenzel2, Vladimir Lazarevic2

  • 1Unité de nutrition, Service endocrinologie, diabétologie, hypertension et nutrition, Département des spécialités de médecine, HUG, 1211 Genève 14.

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Gut microbiota imbalance, or dysbiosis, is linked to weight changes. Altered gut bacteria in malnutrition suggests potential therapeutic targets for weight gain, though more research is needed.

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Area of Science:

  • Microbiology
  • Nutrition Science
  • Gastroenterology

Context:

  • Growing evidence links gut microbiota to human health and disease.
  • Gut dysbiosis is increasingly recognized as a factor in metabolic disorders, including malnutrition.
  • Understanding the gut microbiome's role is crucial for developing novel therapeutic strategies.

Purpose:

  • To review and summarize current knowledge on the relationship between gut microbiota and malnutrition.
  • To highlight alterations in gut bacterial diversity and richness observed in malnourished individuals.
  • To discuss emerging therapeutic interventions targeting the gut microbiota for weight management.

Summary:

  • Malnourished individuals exhibit distinct gut bacterial profiles compared to healthy controls, characterized by altered diversity and richness.
  • Interventions such as probiotics, prebiotics, and fecal microbiota transplantation show promise in modulating the gut microbiota for weight gain.
  • Early studies indicate that manipulating the gut microbiome may be a viable strategy for addressing malnutrition.

Impact:

  • This review provides a comprehensive overview of the gut microbiota's role in malnutrition.
  • It highlights the potential of microbiome-targeted therapies for treating malnutrition and related weight issues.
  • Further research is essential to translate these findings into effective clinical treatments for malnutrition.