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    Area of Science:

    • Biomedical Engineering
    • Biosensor Technology
    • CMOS Systems

    Background:

    • Cell viability monitoring is crucial for drug discovery and toxicology.
    • Existing methods for cell monitoring can be time-consuming and labor-intensive.
    • Integrated lab-on-chip systems offer potential for high-throughput, real-time analysis.

    Purpose of the Study:

    • To develop and characterize a capacitance sensor array for monitoring cell viability.
    • To demonstrate the system's capability for on-chip tracking of cell adhesion and proliferation.
    • To validate the sensor's performance using human ovarian cancer cells.

    Main Methods:

    • Incorporation of a capacitance sensor array into a lab-on-CMOS system.
    • Development of analytical models and calibration procedures for the biosensor.
    • In vitro experiments involving cell culture, capacitance measurements, and microscopic validation.

    Main Results:

    • The capacitance sensor array demonstrated a sensitivity of 590 kHz/fF.
    • On-chip tracking of cell adhesion and monitoring of cell viability were successfully achieved.
    • Capacitance responses correlated with cell proliferation and adhesion, with an estimated response of 100 aF/cell for live cells.

    Conclusions:

    • The lab-on-CMOS capacitance sensor array is a viable tool for label-free, real-time monitoring of cell viability and adhesion.
    • The system offers high sensitivity and accuracy for quantifying cellular changes.
    • This technology has potential applications in drug screening, toxicology, and fundamental cell biology research.