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Related Experiment Video

Updated: Feb 9, 2026

A Mouse Model of Fatigue Induced by Peripheral Irradiation

A Mouse Model of Fatigue Induced by Peripheral Irradiation

Published on: March 17, 2017

Fatigue, a major still underestimated issue.

Carla Ida Ripamonti¹, Andrea Antonuzzo², Paolo Bossi³

¹Oncology-Supportive Care in Cancer Unit, Department of Onco-Haematology, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian, Milan.

Current Opinion in Oncology

|June 8, 2018

Summary

Cancer-related fatigue (CRF) is a common yet undertreated symptom. Guidelines exist for screening and managing CRF, but implementation barriers hinder clinical practice, necessitating further research.

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Last Updated: Feb 9, 2026

A Mouse Model of Fatigue Induced by Peripheral Irradiation

A Mouse Model of Fatigue Induced by Peripheral Irradiation

Published on: March 17, 2017

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Area of Science:

Oncology
Palliative Care
Symptom Management

Background:

Cancer-related fatigue (CRF) is a prevalent and distressing symptom across all cancer stages.
CRF is frequently underreported, inadequately assessed, and undertreated in clinical settings.

Purpose of the Study:

To review current understanding and clinical practice regarding cancer-related fatigue.
To highlight the gap between available guidelines and their implementation in patient care.

Main Methods:

Review of international guidelines for cancer-related fatigue management.
Analysis of barriers to guideline implementation in clinical practice.

Main Results:

International guidelines recommend regular screening for CRF at all cancer care points.
Barriers exist that impede the consistent application of these guidelines in routine oncology care.
Treatable contributing factors and subsequent pharmacological/non-pharmacological interventions are key components of management.

Conclusions:

Despite established guidelines, significant challenges remain in the clinical assessment and management of CRF.
Further research is essential to refine assessment tools, develop improved treatments, and overcome implementation barriers for CRF guidelines.