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Related Experiment Video

Updated: Feb 9, 2026

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

TAM 2.0: tool for MicroRNA set analysis.

Jianwei Li^1,2, Xiaofen Han¹, Yanping Wan¹

¹Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin 300401, China.

Nucleic Acids Research

|June 8, 2018

Summary

This summary is machine-generated.

The updated TAM 2.0 server offers enhanced analysis of microRNA (miRNA) functions and disease links. This resource aids researchers in understanding miRNA roles by providing expanded datasets and new analytical tools for miRNA expression profiles.

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Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

High-throughput microRNA (miRNA) expression profiling generates vast data.
Analyzing functional and disease associations of miRNAs requires up-to-date resources.

Purpose of the Study:

To introduce TAM 2.0, an updated web server for miRNA set enrichment analysis.
To provide an expanded and improved resource for miRNA-disease and miRNA-function associations.

Main Methods:

Manual curation of over 9000 scientific papers.
Development of TAM 2.0 with expanded miRNA set annotations.
Implementation of overrepresentation and correlation analyses for miRNA data.

Main Results:

TAM 2.0 features a two-fold increase in reference miRNA sets compared to its predecessor.
The server includes 9945 miRNA-disease and 1584 miRNA-function associations.
New functionalities include miRNA set query and result visualization.

Conclusions:

TAM 2.0 is a valuable, updated resource for miRNA set enrichment analysis.
The server facilitates the investigation of miRNA roles in biological functions and diseases.
Enhanced analytical capabilities and data expand the utility for the research community.