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Related Concept Videos

Locus of Control01:26

Locus of Control

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Locus of control describes how individuals perceive the causes of events in their lives, influencing motivation and well-being. Introduced by Julian Rotter in 1954, it is categorized into internal and external locus of control.Internal Locus of ControlIndividuals with an internal locus of control believe their actions determine outcomes, fostering responsibility, self-efficacy, and motivation. For example, an employee may attribute career success to hard work. Research links this mindset to...
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
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Root-Locus Method01:19

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A cruise control system in a car is designed to maintain a specified speed automatically by adjusting the gas pedal. The system continuously measures the vehicle's speed and makes fine adjustments to the pedal to achieve this goal. The root locus method is particularly useful for understanding how the cruise control system's behavior changes under varying conditions, such as when the car goes uphill, downhill, or faces strong wind resistance.
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Construction of Root Locus01:15

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The construction of a root locus involves several key steps to analyze and visualize the behavior of a system's poles with varying gain. The number of branches in the root locus equals the number of closed-loop poles and is symmetrical about the real axis.
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Properties of the Root Locus01:05

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The root locus method is an invaluable tool for analyzing higher-order systems without needing to factor the denominator of the transfer function. A pole of the system is identified when the characteristic polynomial in the transfer function's denominator equals zero.
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Updated: Feb 9, 2026

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LOLAweb: a containerized web server for interactive genomic locus overlap enrichment analysis.

V P Nagraj1, Neal E Magee1, Nathan C Sheffield2,3

  • 1School of Medicine Research Computing, University of Virginia, USA.

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|June 8, 2018
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Summary

LOLAweb provides an interactive tool for analyzing genomic region overlaps, connecting new functional genomics data with existing annotations. This web server allows dynamic exploration of enrichment results for regulatory DNA research.

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Area of Science:

  • Genomics
  • Bioinformatics

Background:

  • Growing interest in regulatory DNA function has led to increased functional genomics data generation.
  • Enrichment analysis of genomic region overlaps is a key method for integrating new data with existing annotations.

Purpose of the Study:

  • To introduce LOLAweb, an interactive web server for performing enrichment analysis of genomic locus overlaps.
  • To provide a user-friendly interface for connecting query genomic ranges with a comprehensive database of region sets.

Main Methods:

  • Developed LOLAweb as a web server utilizing an R Shiny application for interactive visualization.
  • Implemented a scalable Linux container for deployment, supporting concurrent users and local installations.

Main Results:

  • LOLAweb accepts user-defined genomic ranges for enrichment testing against a curated database.
  • Results are dynamically visualized, allowing users to filter, sort, and explore overlap enrichments interactively.

Conclusions:

  • LOLAweb offers a scalable and accessible platform for functional genomics data analysis.
  • The tool facilitates the interpretation of new genomic data by linking it to established annotations through interactive enrichment analysis.