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Updated: Feb 9, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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The association between septicemia and the risk of multiple sclerosis: a nationwide register-based retrospective

C-L Tsai1,2, J-T Lee1,2, L-M Lien3,4

  • 1From the Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

QJM : Monthly Journal of the Association of Physicians
|June 8, 2018
PubMed
Abstract

Insights

Septicemia significantly increases the risk of developing multiple sclerosis (MS). Prompt treatment and prevention of septicemia may help reduce the risk of MS.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a primary inflammatory demyelinating condition of the central nervous system.
  • Limited research has explored the connection between septicemia and the risk of developing MS.

Purpose of the Study:

  • This study aimed to investigate the potential association between septicemia and an increased risk of MS.

Main Methods:

  • A retrospective cohort study utilized data from the National Health Insurance Research Database (2001-2011).
  • Nearly 500,000 patients with septicemia were compared to over 1.8 million controls, matched for age and gender.
  • Cox proportional-hazards regression models were employed to calculate hazard ratios (HR) for MS incidence.

Main Results:

  • Patients with septicemia exhibited a 3.06-fold higher risk of developing MS compared to controls.
  • Increased septicemia severity correlated with a higher MS risk (moderate: HR=4.03; severe: HR=11.1).
  • This association was observed in both male and female patients, with higher risks noted in males.

Conclusions:

  • The findings suggest a significant link between septicemia and an elevated risk of MS.
  • Proactive prevention and management of septicemia could be a crucial strategy in mitigating MS risk.

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