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Checkpoint blockade in esophagogastric cancer
Noah A Cohen1, Vivian E Strong1, Yelena Y Janjigian2
1Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Immune checkpoint blockade therapy, including the PD-1 inhibitor pembrolizumab, offers a promising treatment for advanced esophagogastric adenocarcinoma after other therapies fail. This approach is vital for patients with limited options.
Area of Science:
- Oncology
- Immunotherapy
Background:
- Metastatic esophagogastric adenocarcinomas have limited treatment options post-second-line chemotherapy.
- Immune checkpoint blockade represents a novel therapeutic strategy.
Purpose of the Study:
- To review current data on immune checkpoint blockade therapy for advanced esophagogastric adenocarcinoma.
- To highlight the role of PD-1 inhibitors like pembrolizumab.
Main Methods:
- Literature review of clinical data and studies.
- Analysis of treatment outcomes for immune checkpoint inhibitors.
Main Results:
- Pembrolizumab (a PD-1 inhibitor) is approved for advanced/recurrent gastric/gastroesophageal junction cancer post-second-line therapy.
- Immune checkpoint blockade shows promise in selected patients.
Conclusions:
- Immune checkpoint blockade is an important emerging treatment for advanced esophagogastric adenocarcinoma.
- Further research supports its use in patients with limited therapeutic alternatives.
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