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Women with bleeding disorders.

C Hermans1, R Kulkarni2

  • 1Haemostasis and Thrombosis Unit, Division of Haematology, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|June 8, 2018
PubMed
Summary
This summary is machine-generated.

Genetic diagnosis for haemophilia carriers is easier, yet delays persist. Women with von Willebrand disease (VWD) and rare factor deficiencies (RFD) require specialized care during pregnancy and postpartum to prevent bleeding complications.

Keywords:
carrierdeliveryhaemophiliapregnancyrare clotting factor deficiencyvon Willebrand disease

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Area of Science:

  • Hematology
  • Genetics
  • Obstetrics

Background:

  • Advances in genetic testing facilitate diagnosis of haemophilia carriers.
  • Despite increased awareness, delays in diagnosis and management for carriers with bleeding symptoms are common.
  • Women with von Willebrand disease (VWD) and rare factor deficiencies (RFD) face risks during pregnancy and childbirth.

Purpose of the Study:

  • To review the evolution of care for girls and women in haemophilia families.
  • To identify unmet needs and available options for managing VWD and RFD in women.
  • To provide recommendations for pregnancy, delivery, and postpartum care in these patient groups.

Main Methods:

  • Literature review of clinical practice and genetic techniques.
  • Analysis of clinical and laboratory characteristics in pregnant women with VWD and RFD.
  • Synthesis of current recommendations for obstetric and postpartum management.

Main Results:

  • Genetic diagnosis is more accessible, but timely management remains a challenge.
  • Women with VWD and RFD are at risk for bleeding and adverse fetal/neonatal outcomes.
  • Specific clinical and laboratory findings during pregnancy require tailored management strategies.

Conclusions:

  • Improved diagnostic accessibility must be matched by efficient management pathways.
  • Specialized care is crucial for women with VWD and RFD throughout pregnancy and postpartum.
  • Evidence-based recommendations are needed to optimize outcomes for mothers and infants.