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Session 2: Mutational discordance: the big challenge in personalized treatments - any solutions?

M Siddiqui1, M Chand2, C Eng3

  • 1The Royal Marsden NHS Foundation Trust, Croydon University Hospital, Croydon, UK.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|June 8, 2018
PubMed

Insights

Personalized cancer therapy faces challenges due to limited molecular markers. Real-time analysis of tumor mutations could enable timely, effective treatments for metastatic disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Metastatic cancer treatment requires personalized, targeted therapies for optimal outcomes.
  • Current molecular markers are insufficient for reliably guiding newer chemotherapy choices.

Purpose of the Study:

  • To discuss challenges in delivering timely, molecularly-guided cancer treatments.
  • To explore the potential of real-time tumor mutation analysis during disease progression.

Main Methods:

  • Review of current challenges in personalized oncology.
  • Discussion of molecular profiling and its limitations.
  • Exploration of real-time mutational analysis concepts.

Main Results:

  • Limited frequency and reliability of current molecular markers hinder personalized therapy.
  • Timely and effective treatment decisions are challenged by current diagnostic methods.

Conclusions:

  • Personalized cancer treatment necessitates improved molecular markers.
  • Real-time analysis of tumor mutational changes offers a promising avenue for adaptive therapy during progression.

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