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Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae
Jaeyoung Kwon1, Hyaemin Lee, Young Hye Seo2,3
1Natural Constituents Research Center , Korea Institute of Science and Technology (KIST) Gangneung Institute , Gangneung 25451 , Republic of Korea.
Abstract:
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
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