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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
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DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
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Social Traps01:41

Social Traps

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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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Gene Conversion02:08

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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NSAIDs hypersensitivity: questions not resolved.

Natalia Blanca-Lopez1, Maria L Somoza-Alvarez1, Teresa Bellon2

  • 1Allergy Service Infanta Leonor University Hospital.

Current Opinion in Allergy and Clinical Immunology
|June 8, 2018
PubMed
Summary
This summary is machine-generated.

Hypersensitivity reactions (HSR) to nonsteroidal anti-inflammatory drugs (NSAIDs) affect all ages and are classified by immune response or prostaglandin pathway involvement. Precise evaluation and management are crucial for these common drug reactions.

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Area of Science:

  • Immunology
  • Pharmacology
  • Allergy

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed globally.
  • Hypersensitivity reactions (HSR) to NSAIDs are a significant clinical concern across all age groups.
  • NSAID-induced HSR mechanisms include adaptive immune responses (IgE, T-cell) and prostaglandin pathway abnormalities.

Purpose of the Study:

  • To review current classifications and understanding of NSAID hypersensitivity.
  • To highlight the complexity in evaluating NSAID-exacerbated respiratory disease, cutaneous disease, and urticaria.
  • To discuss mechanisms of selective responders and cross-intolerant NSAID reactions.

Main Methods:

  • Review of recent classifications based on clinical symptoms, timing, cross-reactivity, and underlying conditions.
  • Categorization of NSAID hypersensitivity into selective responders and cross-intolerant groups.
  • Identification of specific subgroups like NSAIDs-exacerbated respiratory disease and NSAIDs-induced urticaria.

Main Results:

  • Established classifications now recognize distinct categories within NSAID hypersensitivity.
  • Complex subgroups include NSAIDs-exacerbated respiratory disease, cutaneous disease, and urticaria/angioedema.
  • Selective responders involve drug-specific IgE or T-cell responses; new mixed reactions are identified.

Conclusions:

  • Accurate patient evaluation using established guidelines is essential for improved understanding and management of NSAID hypersensitivity.
  • Further research is warranted due to the significant number of patients affected by NSAID HSR.
  • Improved diagnostic and management strategies are needed for NSAID hypersensitivity.