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Updated: Feb 9, 2026
08:15
Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
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Post-treatment and spontaneous HIV control.
Genevieve E Martin1, John Frater1,2
1Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research.
Current Opinion in HIV and AIDS
|June 8, 2018
Summary
Defining virological remission is crucial for HIV cure research. This review examines predictors and mechanisms of HIV control after treatment interruption, emphasizing the need for clear definitions.
Area of Science:
- Virology
- Immunology
- HIV Research
Background:
- Antiretroviral therapy (ART) has transformed HIV management.
- The HIV cure field is increasingly focused on achieving virological remission.
- Understanding spontaneous and post-treatment control is key to developing effective HIV cure strategies.
Purpose of the Study:
- To review evidence on virological remission in individuals with HIV on ART and those untreated.
- To explore predictors and mechanisms of spontaneous and post-treatment HIV control.
- To discuss the importance of defining 'controller' phenotypes for HIV cure research.
Main Methods:
- Literature review of recent data on HIV control.
- Exploration of the role of the HIV reservoir in virological control.
- Analysis of challenges in studying treatment interruption and reservoir dynamics.
Main Results:
- Post-treatment control and remission are key endpoints in HIV cure trials.
- The HIV reservoir plays a significant role in determining control.
- Treatment interruption safety and acceptability are critical considerations.
Conclusions:
- Consensus on definitions for different forms of HIV control is urgently needed.
- Standardized definitions will enhance comparability and robustness of HIV cure trial results.
- Achieving virological remission is a primary goal for interventions aimed at an HIV cure.
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