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The influence of sex on left ventricular strain in hypertensive population

Marijana Tadic1, Cesare Cuspidi2, Vera Celic1

  • 1University Clinical Hospital Center 'Dr Dragisa Misovic - Dedinje', Department of Cardiology, Belgrade, Serbia.

Journal of Hypertension
|June 8, 2018
PubMed

Insights

Hypertension significantly reduces left ventricular strains in both sexes, with greater impairment observed in men. Sex influences how arterial hypertension affects cardiac mechanics, particularly longitudinal and circumferential strains.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Medical Imaging

Background:

  • Arterial hypertension is a major risk factor for cardiovascular disease.
  • Sex-based differences in cardiovascular health and disease progression are increasingly recognized.
  • Left ventricular mechanics play a crucial role in cardiac function and are affected by hypertension.

Purpose of the Study:

  • To investigate the influence of sex on left ventricular (LV) mechanics in individuals with hypertension.
  • To compare LV strain and twist between hypertensive men and women.
  • To understand the interaction between sex and hypertension on LV function.

Main Methods:

  • Cross-sectional study involving 171 untreated hypertensive patients and 112 normotensive controls.
  • 24-hour ambulatory blood pressure monitoring.
  • Comprehensive echocardiographic examination including LV strain assessment (longitudinal, circumferential, radial) and LV twist analysis.

Main Results:

  • Hypertensive individuals of both sexes exhibited reduced LV global longitudinal and circumferential strains compared to normotensive controls.
  • LV longitudinal and circumferential strains were significantly lower in hypertensive men than in women.
  • LV twist was significantly higher in hypertensive women than in hypertensive men.

Conclusions:

  • Hypertension significantly impairs LV longitudinal and circumferential strains, with a more pronounced effect in men.
  • Sex is a significant factor influencing the relationship between hypertension and LV mechanics.
  • These findings highlight the importance of considering sex in the evaluation and management of hypertensive heart disease.
Abstract

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