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Deep cerebral microbleeds are associated with the severity of lacunar infarcts and hypertension: A retrospective

Zhongbao Gao1, Yongzhi Zhai, Xingli Zhao

  • 1Department of Healthcare, Nanlou Division Department of Emergency Department of Geriatric Neurology, Nanlou Division Department of Neurology, Chinese PLA General Hospital, Beijing, China.

Medicine
|June 8, 2018
PubMed

Insights

Deep cerebral microbleeds (CMBs) are linked to lacunar infarcts, unlike lobar or infratentorial CMBs. This finding clarifies the spatial relationship in cerebral small vessel disease, aiding in understanding stroke risk factors.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Cerebral microbleeds (CMBs) and lacunar infarcts are key indicators of cerebral small vessel disease.
  • The precise relationship between the anatomical location of CMBs and lacunar infarcts remains incompletely understood.

Purpose of the Study:

  • To investigate the association between the specific locations of CMBs and the presence, number, and severity of lacunar infarcts.
  • To clarify if CMB distribution patterns correlate with lacunar infarct characteristics.

Main Methods:

  • Retrospective analysis of 166 patients with ischemic stroke or transient ischemic attacks.
  • Assessment of CMB location using the Microbleed Anatomical Rating Scale on T2*-weighted angiography.
  • Correlation analysis between CMB location and lacunar infarct parameters, including number and white matter hyperintensity severity.

Main Results:

  • CMBs were identified in 46.4% of patients.
  • Deep CMBs showed a significant association with both the number (OR 1.18) and severity (OR 1.71) of lacunar infarcts.
  • Lobar and infratentorial CMBs did not demonstrate a significant association with lacunar infarcts.

Conclusions:

  • Deep cerebral microbleeds are specifically associated with lacunar infarcts, suggesting a localized pathophysiological link.
  • The location of CMBs, particularly deep-seated ones, is a critical factor in understanding the manifestation of cerebral small vessel disease.

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