Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.5K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.5K
Vapor Pressure Lowering03:28

Vapor Pressure Lowering

31.4K
The equilibrium vapor pressure of a liquid is the pressure exerted by its gaseous phase when vaporization and condensation are occurring at equal rates:
31.4K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.4K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.4K
Subviral Agents01:29

Subviral Agents

580
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
580
Air-entraining Agents01:27

Air-entraining Agents

276
Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
276
Masking and Demasking Agents01:19

Masking and Demasking Agents

3.6K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperlipidemia management: A calibrated approach.

The Journal of family practice·2023
Same author

Arterial Atherosclerosis: Vascular Surgery Interventions.

American family physician·2022
Same author

Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.

American family physician·2020
Same author

Lower Extremity Peripheral Artery Disease: Diagnosis and Treatment.

American family physician·2019
Same author

CV risk prediction tools: Imperfect, Yes, but are they serviceable?

The Journal of family practice·2018
Same author

Estimating Cardiovascular Risk.

American family physician·2017

Related Experiment Video

Updated: Feb 9, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.1K

Newer cholesterol-lowering agents: What you must know.

Jonathon M Firnhaber1

  • 1Brody School of Medicine, East Carolina University, Greenville, NC, USA.

The Journal of Family Practice
|June 8, 2018
PubMed
Summary

For lowering LDL cholesterol, consider interventions that increase LDL receptor expression. While PCSK9 inhibitors are effective with statins, they represent a costly option.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Elevated low-density lipoprotein cholesterol (LDL-C) is a major risk factor for cardiovascular disease.
  • Statins are first-line therapy but may not sufficiently lower LDL-C in all patients.
  • Non-statin interventions are needed to further reduce LDL-C levels.

Purpose of the Study:

  • To evaluate therapeutic strategies for upregulating LDL-C receptor expression.
  • To assess the efficacy and cost-effectiveness of PCSK9 inhibitors as an adjunct to statin therapy.

Main Methods:

  • Review of existing literature on lipid-lowering interventions.
  • Analysis of studies investigating mechanisms of LDL-C receptor regulation.
  • Comparative assessment of PCSK9 inhibitors versus other non-statin agents.

More Related Videos

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay
08:18

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

Published on: January 7, 2019

9.6K
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

13.1K

Related Experiment Videos

Last Updated: Feb 9, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.1K
High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay
08:18

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

Published on: January 7, 2019

9.6K
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

13.1K

Main Results:

  • Interventions that upregulate LDL-C receptor expression are a key strategy for lowering LDL-C.
  • PCSK9 inhibitors effectively reduce LDL-C when added to statin therapy.
  • The high cost of PCSK9 inhibitors is a significant consideration for widespread adoption.

Conclusions:

  • Targeting LDL-C receptor expression is a viable approach for managing hypercholesterolemia.
  • PCSK9 inhibitors offer a potent but expensive option for patients requiring further LDL-C reduction.
  • Cost-effectiveness analyses are crucial when considering non-statin lipid-lowering therapies.