Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...

Peptic Ulcer Disease IV: Management

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Memory Sticks: A Humorous Review of Medical Training.

Family medicine·2023

Same author

Caring for the Forcibly Displaced.

Primary care·2021

Same author

Impact of Academic Detailing and Same-Day Reminders on Monitoring for Iron Deficiency in Patients With Heart Failure in a Family Medicine Residency.

PRiMER (Leawood, Kan.)·2020

Same author

Immigrant and Refugee Health in North Carolina.

North Carolina medical journal·2019

Same author

Fear.

Family medicine·2019

Same author

Same Content, Different Methods: Comparing Lecture, Engaged Classroom, and Simulation.

Family medicine·2018

Search research articles

Related Experiment Video

Updated: Feb 9, 2026

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

Photo Rounds: Painless penile ulcer and tender inguinal lymphadenopathy.

Jeffrey Walden¹, Raleigh Rumley²

¹University of North Carolina, Chapel Hill, NC, and Cone Health Family Residency, Greensboro, NC, USA.

The Journal of Family Practice

|June 8, 2018

Summary

A patient treated for syphilis experienced persistent symptoms, leading to further testing. This revealed a misdiagnosis, with the patient actually being treated for the incorrect sexually transmitted disease (STD).

More Related Videos

Intravital Microscopy of the Inguinal Lymph Node

Intravital Microscopy of the Inguinal Lymph Node

Published on: April 4, 2011

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

Related Experiment Videos

Last Updated: Feb 9, 2026

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

Intravital Microscopy of the Inguinal Lymph Node

Intravital Microscopy of the Inguinal Lymph Node

Published on: April 4, 2011

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

Area of Science:

Infectious Diseases
Microbiology
Public Health

Background:

Sexually transmitted diseases (STDs) require accurate and timely diagnosis for effective treatment.
Syphilis is a bacterial infection that can have serious long-term health consequences if left untreated or misdiagnosed.

Observation:

A patient presented with persistent symptoms despite prior treatment for syphilis.
Initial treatment for syphilis did not resolve the patient's clinical presentation.

Findings:

Further diagnostic investigations identified a misdiagnosis.
The patient was receiving treatment for an incorrect sexually transmitted disease (STD).

Implications:

Highlights the critical importance of accurate STD diagnostics to prevent treatment delays and complications.
Underscores the need for comprehensive diagnostic approaches when initial treatments are ineffective.
Emphasizes the public health challenge posed by misdiagnosed infectious diseases.