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Association of Pediatric Atopic Dermatitis and Cataract Development and Surgery

Hyun Sun Jeon1, Mira Choi2, Seong Jun Byun1

  • 1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

JAMA Ophthalmology
|June 8, 2018
PubMed

Insights

Pediatric patients with atopic dermatitis (AD) show a higher risk of needing cataract surgery. Severe AD may also increase the risk of developing cataracts and requiring surgery.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Epidemiology

Background:

  • Atopic dermatitis (AD) is a common inflammatory skin condition.
  • Data on the risk of cataract development in pediatric patients with AD is limited.

Purpose of the Study:

  • To investigate the association between atopic dermatitis (AD) and the subsequent risk of cataract development and cataract surgery in children.
  • To assess the impact of AD severity on these risks.

Main Methods:

  • Population-based retrospective longitudinal cohort study using Korean National Health Insurance Service data (2002-2013).
  • Matched incident pediatric AD cases (n=34,375) with controls (n=137,500) using propensity scores.
  • Kaplan-Meier methods and Cox proportional hazard models were used to compare outcomes and identify risk factors.

Main Results:

  • Cataract development did not significantly differ between AD patients and controls.
  • Cataract surgery was more frequent in the AD cohort compared to controls (P=.02).
  • Severe AD was associated with an increased risk of cataract development (aHR=1.94) and cataract surgery (aHR=5.48).

Conclusions:

  • While the absolute risk of cataract is low in children, those with AD have an elevated risk of requiring cataract surgery.
  • Disease severity in pediatric AD appears to be a significant factor influencing the risk of both cataract development and the need for surgery.
Abstract

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