Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

1.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.3K
Teeth01:15

Teeth

1.8K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.8K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

18.9K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

4.0K
4.0K
Bone Cells and Tissue01:30

Bone Cells and Tissue

8.4K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.4K
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

3.5K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From gut to brain: effects of fecal microbiota transplants from humans to rats on hippocampal gene regulation - a study on anorexia nervosa.

Translational psychiatry·2026
Same author

Impact of Myb deficiency on Rankl/Opg expression within the developing mouse mandible.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2025
Same author

The Influence of Omega-3 Fatty Acids and Probiotics on Hippocampal Inflammation and Glial Cells in a Chronic Anorexia Nervosa Rat Model.

The International journal of eating disorders·2025
Same author

Is there a relationship between tumour aggressiveness and ovarian stimulation outcomes in adolescent and young adult patients with lymphoma?

Reproductive biomedicine online·2025
Same author

Continuum Excitations in a Spin Supersolid on a Triangular Lattice.

Physical review letters·2024
Same author

Metabolic biomarkers and cardiovascular risk stratification in hypertension.

Hipertension y riesgo vascular·2024
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.3K

Bone Marrow Stromal Cells Promote Innervation of Bioengineered Teeth.

M Strub1,2,3, L Keller1,2, Y Idoux-Gillet1,2

  • 11 INSERM (French National Institute of Health and Medical Research), Regenerative NanoMedicine (RNM), FMTS, Strasbourg, France.

Journal of Dental Research
|June 8, 2018
PubMed
Summary
This summary is machine-generated.

Bone marrow mesenchymal stem cells (BMDCs) promote innervation of bioengineered teeth by reducing immune response and releasing growth factors. This strategy offers a potential method for innervating dental implants without immunosuppressants.

Keywords:
axonscell differentiationmesenchymal stromal cellsodontogenesistissue engineeringtrigeminal ganglia

More Related Videos

Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice
08:07

Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice

Published on: January 6, 2018

32.7K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

5.8K

Related Experiment Videos

Last Updated: Feb 9, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.3K
Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice
08:07

Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice

Published on: January 6, 2018

32.7K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

5.8K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Tooth innervation is crucial for function but does not regenerate spontaneously after injury.
  • Previous attempts at bioengineered tooth regeneration with trigeminal ganglion coimplantation failed to achieve innervation.
  • Bone marrow-derived cells (BMDCs) have shown potential in promoting axonal regeneration in other contexts.

Purpose of the Study:

  • To verify the stemness of isolated BMDCs.
  • To confirm the role of BMDCs in the innervation of bioengineered teeth.
  • To elucidate the mechanisms underlying BMDC-mediated tooth innervation.

Main Methods:

  • Cultured reassociations of dental mesenchymal cells and BMDCs-GFP with dental epithelium.
  • Subcutaneous coimplantation with trigeminal ganglion in mice.
  • Analysis of innervation using histology, immunofluorescence, and gene/protein expression (qRT-PCR, immunostainings).

Main Results:

  • Axons successfully penetrated the dental pulp and reached the odontoblast layer in bioengineered teeth.
  • BMDCs were found associated with axons within the dental pulp.
  • BMDCs modulated the immune response by reducing T lymphocytes and expressed neurotrophic factors (NGF, BDNF, NT3).

Conclusions:

  • BMDCs significantly promote the innervation of bioengineered teeth.
  • Innervation occurs via immunomodulation and expression of neurotrophic factors by BMDCs.
  • This approach offers a promising strategy for innervating bioengineered teeth without immunosuppressive drugs, avoiding side effects.