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Uric acid in aortic dissection: A meta-analysis
Xiaodong Li1, Shanshan Jiang1, Jiaan He1
1Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Summary
Serum uric acid (SUA) levels are significantly higher in patients with aortic dissection compared to controls. This meta-analysis suggests elevated SUA may play a role in the condition's development.
Area of Science:
- Cardiovascular Research
- Biomarkers
- Medical Diagnostics
Background:
- Conflicting findings exist regarding serum uric acid (SUA) levels in aortic dissection patients.
- Understanding the relationship between SUA and aortic dissection is crucial for diagnosis and treatment.
Purpose of the Study:
- To conduct a meta-analysis comparing serum uric acid (SUA) levels in aortic dissection patients versus control groups.
- To synthesize existing evidence on SUA levels in aortic dissection.
Main Methods:
- Systematic literature search of multiple databases (PubMed, Embase, etc.) up to January 2018.
- Inclusion of all observational studies comparing SUA levels in aortic dissection patients and controls.
- Utilized weighted mean difference (WMD) with 95% confidence intervals (CI) for pooled analysis.
Main Results:
- Seven case-control studies with 1197 patients and 1193 controls were analyzed.
- Significantly higher SUA levels were found in aortic dissection patients (WMD 58.22 μmol/L; 95% CI 26.71-89.73).
- No significant difference in SUA levels was observed between Stanford type A and type B aortic dissection.
Conclusions:
- This meta-analysis confirms significantly elevated SUA levels in aortic dissection patients compared to controls.
- Elevated SUA may contribute to the pathogenesis of aortic dissection.
- Further research is warranted to determine if SUA is an independent risk factor for aortic dissection.
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