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MEF2 and the tumorigenic process, hic sunt leones

Eros Di Giorgio1, Wayne W Hancock2, Claudio Brancolini1

  • 1Department of Medicine, Università degli Studi di Udine, P.le Kolbe 4, 33100 Udine, Italy.

Biochimica Et Biophysica Acta. Reviews on Cancer
|June 8, 2018
PubMed

Insights

Myocyte enhancer factor 2 (MEF2) transcription factors are implicated in cancer development. Further research is needed to clarify the role of MEF2 alterations in tumorigenesis and identify therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Myocyte enhancer factor 2 (MEF2) transcription factors are crucial for cell fate and adaptive responses.
  • Recent studies reveal diverse genetic alterations of MEF2 across various cancers.
  • The precise impact of these MEF2 alterations on cancer initiation and progression remains incompletely understood.

Purpose of the Study:

  • To review the current understanding of MEF2 transcription factors in the context of cancer.
  • To highlight the need for deeper insights into MEF2 regulation and mutation consequences in malignant cells.

Main Methods:

  • Literature review of recent studies on MEF2 in cancer.
  • Analysis of the molecular pathways regulating MEF2 expression and function.
  • Examination of the nature and consequences of MEF2 mutations in tumorigenesis.

Main Results:

  • MEF2 transcription factors play multifaceted roles in cancer.
  • Genetic alterations in MEF2 are linked to the triggering and maintenance of the tumorigenic process.
  • Understanding MEF2

Conclusions:

  • MEF2 transcription factors are significantly involved in cancer.
  • Further investigation into MEF2
Keywords:
Class IIa HDACMEF2AMEF2BMEF2CMEF2DP300

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