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Dendritic cells in inflammatory angiogenesis and lymphangiogenesis
Daniela Bosisio1, Roberto Ronca1, Valentina Salvi1
1Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Current Opinion in Immunology
|June 8, 2018
Summary
Inflammation requires lymph node expansion, supported by blood and lymph vessel development. Human dendritic cells (DCs), particularly conventional DCs (cDCs), promote this angiogenesis through VEGF factors, while plasmacytoid DCs (pDCs) roles are less understood.
Area of Science:
- Immunology
- Vascular Biology
- Cell Biology
Background:
- Lymph node (LN) expansion is crucial for immune responses during inflammation.
- This expansion depends on the development of blood and lymphatic vessels.
- Human dendritic cells (DCs), comprising conventional DCs (cDCs) and plasmacytoid DCs (pDCs), are key immune cells involved in inflammation regulation.
Purpose of the Study:
- To investigate the role of human dendritic cells (DCs) in regulating angiogenesis within lymph nodes.
- To explore the specific contributions of conventional DCs (cDCs) and plasmacytoid DCs (pDCs) to vascular development during inflammation.
Main Methods:
- Analysis of DC subsets (cDCs and pDCs) and their secreted mediators.
- Assessment of angiogenic factor production, including VEGF-A and VEGF-C.
- Investigation of DC-mediated effects on neovascular formation and transdifferentiation processes.
Main Results:
- Conventional DCs (cDCs) directly and indirectly support angiogenesis in secondary LNs.
- cDCs secrete vascular endothelial growth factor-A (VEGF-A) and VEGF-C, promoting blood and lymph vessel development.
- Plasmacytoid DCs (pDCs) have largely unexplored angiogenic properties compared to cDCs.
Conclusions:
- Conventional DCs (cDCs) play a significant role in promoting lymph node angiogenesis through the secretion of specific growth factors.
- Further research is needed to elucidate the angiogenic potential and functions of plasmacytoid DCs (pDCs).
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