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Species and antimicrobial susceptibility testing of coagulase-negative staphylococci in periprosthetic joint

J Lourtet-Hascoët1, M P Félicé1, A Bicart-See1

  • 1Microbiological laboratory, J. Ducuing Hospital,Toulouse,France.

Epidemiology and Infection
|June 9, 2018
PubMed

Insights

Coagulase-negative staphylococci (CNS) cause over half of periprosthetic-joint infections (PJIs) and show high resistance to common antibiotics like methicillin. Linezolid and daptomycin remain effective against these challenging PJI pathogens.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Orthopedic Surgery

Background:

  • Periprosthetic-joint infections (PJIs) are serious complications following joint replacement surgery.
  • Coagulase-negative staphylococci (CNS) are increasingly recognized as significant pathogens in PJIs.
  • Understanding the distribution and antibiotic susceptibility of CNS is crucial for effective treatment.

Purpose of the Study:

  • To determine the prevalence of different coagulase-negative staphylococci (CNS) species causing PJIs.
  • To analyze the antibiotic susceptibility patterns of these CNS strains.
  • To identify effective antibiotic options for CNS PJI management.

Main Methods:

  • A multicentre retrospective study was conducted in France.
  • Data from 215 CNS PJI cases between 2011 and 2015 were analyzed.
  • Species distribution and antibiotic resistance profiles were determined for isolated CNS strains.

Main Results:

  • Staphylococcus epidermidis was the most common CNS species (60%), followed by S. capitis (11%) and S. lugdunensis (10%).
  • Over half (52.1%) of the CNS strains were resistant to methicillin.
  • Linezolid and daptomycin showed complete in vitro activity against all tested CNS strains.

Conclusions:

  • Methicillin resistance exceeds 50% among CNS causing PJIs, with S. epidermidis being the most frequent and resistant species.
  • Emerging species like S. lugdunensis and S. capitis demonstrate more favorable antibiotic susceptibility profiles.
  • Linezolid and daptomycin are highly effective in vitro against CNS involved in PJIs, offering potential therapeutic options.
Keywords:
coagulase-negative staphylococciepidemiologyprosthetic joint infectionsprosthetic joint infections.

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