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A Case Report on Pregabalin-Induced Eosinophilia
Raj Shilpa1, T P Sreekrishnan, K P Gireesh Kumar
1Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa, Amrita University, Amrita Institute of Medical Sciences (AIMS), Kochi, Kerala, India.
Summary
A rare case of eosinophilia, a significant increase in eosinophil cells, was observed in a patient taking pregabalin for diabetic neuropathy. Discontinuation of pregabalin led to a dramatic decrease in eosinophil levels, suggesting a probable drug-induced reaction.
Area of Science:
- Pharmacology
- Adverse Drug Reactions
- Hematology
Background:
- Pregabalin, a gamma-aminobutyric acid derivative, is prescribed for neuropathic pain and seizures.
- Common side effects include drowsiness, dizziness, and weight gain.
Observation:
- A 77-year-old diabetic patient with peripheral neuropathy developed marked eosinophilia (60.3%) during pregabalin therapy.
- Symptoms included paresthesias in the feet, particularly at night.
Findings:
- Upon cessation of pregabalin, eosinophil levels significantly decreased to 7.3% within one month.
- The Naranjo Adverse Drug Reaction scale indicated a probable link between pregabalin and the observed eosinophilia (score of 8).
Implications:
- This case highlights a rare but potential adverse effect of pregabalin, necessitating careful monitoring of eosinophil counts.
- Discontinuation of pregabalin may be warranted in cases of drug-induced eosinophilia.
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