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Pediatric Renal Transplantation: Evaluation of Long-Term Outcomes and Comparison to Adult Population

H Antunes1, B Parada1, E Tavares-da-Silva1

  • 1Department of Urology and Renal Transplantation, Coimbra University Hospital Center, Coimbra, Portugal.

Transplantation Proceedings
|June 9, 2018
PubMed

Insights

Pediatric kidney transplantation outcomes in our department mirror adult results, with similar graft survival rates despite higher acute rejection rates in children. This study analyzed 101 pediatric kidney transplants over 35 years.

Area of Science:

  • Nephrology
  • Pediatric Surgery
  • Transplantation Medicine

Background:

  • Pediatric kidney transplantation constitutes a small fraction (around 4%) of all kidney transplantations in Europe.
  • Understanding the specific outcomes and trends in pediatric renal transplantation is crucial for improving care for this unique patient group.

Purpose of the Study:

  • To analyze the evolution of pediatric renal transplantation within our department over a 35-year period.
  • To compare the outcomes of pediatric renal transplant recipients with those of adult recipients.
  • To identify predictive factors for graft loss and survival in pediatric kidney transplantation.

Main Methods:

  • A retrospective analysis of 101 pediatric renal transplantations performed between January 1981 and December 2016.
  • Evaluation of clinical, analytical, and surgical data to determine factors influencing graft survival.
  • Comparative analysis between pediatric and adult renal transplant populations.

Main Results:

  • Pediatric transplants represented 3.4% of all kidney transplants in the department; 12% involved living donors.
  • Younger donor age was linked to reduced graft survival, and acute rejections were more common in pediatric recipients.
  • One, 5, and 10-year renal graft survival rates were 94.8%, 77.4%, and 66.5%, respectively, with no significant difference compared to adults.

Conclusions:

  • Pediatric renal transplantation demonstrates comparable graft survival rates to adult transplantation.
  • Despite challenges like higher acute rejection rates, pediatric kidney transplant outcomes are consistent with adult benchmarks.
Abstract

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