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Renal Doppler Resistance Indices in Kidney Transplant Recipients With Proteinuria
1Department of Internal Medicine, Division of Nephrology, Bozok University, Yozgat, Turkey.
Transplantation Proceedings
|June 9, 2018
Summary
Proteinuria in kidney transplant recipients can risk graft failure. Doppler ultrasound (DU) indices like resistive index (RI) and pulsatility index (PI) correlate with proteinuria levels and serum creatinine, aiding in risk assessment.
Area of Science:
- Nephrology
- Radiology
- Transplant Surgery
Background:
- Proteinuria is a risk factor for allograft failure in renal transplant recipients.
- Limited understanding exists regarding factors influencing proteinuria and Doppler ultrasound (DU) indices (RI, PI) in these patients.
Purpose of the Study:
- To investigate the relationship between proteinuria levels and DU intrarenal resistive index (RI) and pulsatility index (PI) in renal transplant recipients.
- To identify factors correlating with these indices in patients with proteinuria <1000 mg/24 h.
Main Methods:
- Assessed correlations between DU RI, PI, and proteinuria in 93 renal transplant recipients with varying proteinuria levels (100-999 mg/24 h).
- Patients were monitored by DU for at least 28 months post-transplantation at a single center.
Main Results:
- DU RI and PI values showed variations across proteinuria groups (100-299, 300-499, 500-999 mg/24 h).
- Multivariate analysis revealed significant correlations between DU indices, serum creatinine, donor type, and graft survival across different proteinuria levels.
Conclusions:
- In renal transplant recipients with proteinuria <1000 mg/24 h, DU RI values were <0.72 and PI values were <1.41.
- Correlations were established between proteinuria incidence and DU RI, PI, and serum creatinine levels, suggesting their utility in monitoring.
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