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Safety of Direct-Acting Antiviral Therapy Regarding Renal Function in Post-Liver Transplant Patients Infected with

G Peschel1, L Moleda1, L Baier2

  • 1Department of Gastroenterology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.

Transplantation Proceedings
|June 9, 2018
PubMed

Insights

Direct-acting antiviral (DAA) therapy is safe and effective for liver transplant recipients with hepatitis C virus (HCV). This treatment did not negatively impact renal function, even in patients with pre-existing kidney issues.

Area of Science:

  • Hepatology
  • Virology
  • Nephrology

Background:

  • Hepatitis C virus (HCV) infection in liver transplant (LT) recipients can lead to renal or hepatic impairment.
  • Direct-acting antivirals (DAA) may interact with immunosuppressants, potentially affecting renal function post-LT.

Purpose of the Study:

  • To evaluate the safety and efficacy of DAA therapy in HCV-infected liver transplant patients.
  • To assess the impact of DAA therapy on renal function and liver parameters.

Main Methods:

  • Single-center study of 18 HCV-infected patients post-LT treated with DAA.
  • Primary endpoints: change in glomerular filtration rate (GFR) and sustained virologic response at 12 weeks (SVR12).
  • Secondary endpoints: assessment of transaminases, bilirubin, INR, fibrosis, and MELD score.

Main Results:

  • All patients achieved SVR12, indicating high efficacy.
  • Renal function (GFR) was not significantly affected by DAA therapy, immunosuppression, or pre-existing renal impairment.
  • Liver enzymes and bilirubin levels decreased; fibrosis markers improved in some patients.

Conclusions:

  • DAA therapy is effective and safe in a real-world cohort of LT recipients with HCV.
  • No adverse impact on renal function was observed, even in patients with prior renal impairment.
Abstract

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