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Quantitative Susceptibility Mapping after Sports-Related Concussion
K M Koch1, T B Meier2, R Karr3
1From the Departments of Radiology (K.M.K., R.K., A.S.N.) kmkoch@mcw.edu.
AJNR. American Journal of Neuroradiology
|June 9, 2018
Summary
Quantitative susceptibility mapping (QSM) detects brain tissue changes after sports-related concussion. These magnetic susceptibility changes in white matter persist longer than clinical recovery and correlate with return-to-play time.
Area of Science:
- Neuroimaging
- Biophysics
- Sports Medicine
Background:
- Sports-related concussion can cause subtle brain tissue alterations.
- Quantitative susceptibility mapping (QSM) is an MRI technique sensitive to tissue composition.
- Assessing these changes aids in understanding concussion's impact.
Purpose of the Study:
- To investigate longitudinal changes in brain tissue magnetic susceptibility after sports-related concussion using QSM.
- To compare QSM findings with clinical concussion metrics.
- To explore the relationship between susceptibility changes and recovery time.
Main Methods:
- Longitudinal QSM data were acquired from concussed and control football athletes at 24 hours, 8 days, and 6 months post-injury.
- Analysis focused on white matter and subcortical gray matter compartments.
- Clinical concussion metrics were also measured longitudinally.
Main Results:
- Increased white matter susceptibility was observed in concussed athletes at 24 hours and 8 days post-injury, normalizing by 6 months.
- Subcortical gray matter showed no significant group differences.
- QSM-detected tissue changes persisted longer than clinical recovery metrics and correlated with return-to-play duration.
Conclusions:
- Sports-related concussion induces detectable physiological changes in brain tissue measurable by QSM.
- QSM may offer a more sensitive biomarker of concussion-related brain changes than clinical assessments alone.
- These findings highlight QSM's potential for monitoring concussion recovery and guiding return-to-play decisions.
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