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Neurodevelopmental Correlates of Fetal Motor Behavior Assessed Using Cine MR Imaging
T T A Hayat1, M Martinez-Biarge2, V Kyriakopoulou3
1From the Centre for the Developing Brain (T.T.A.H., V.K., J.V.H., M.A.R.), Perinatal Imaging and Health, Imaging Sciences & Biomedical Engineering Division, King's College London, London, UK tayyib.hayat@nhs.net.
AJNR. American Journal of Neuroradiology
|June 9, 2018
Summary
Fetal motor behavior and brain MRI together can predict neurodevelopmental outcomes. This combined imaging approach enhances the assessment of fetal neurologic integrity and informs postnatal development.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Imaging
Background:
- Fetal motor behavior is a key indicator of healthy development.
- Understanding its link to neurologic integrity requires further investigation.
- Magnetic Resonance (MR) imaging offers comprehensive fetal views, aiding this characterization.
Purpose of the Study:
- To integrate fetal motor behavior analysis, brain MR imaging, and postnatal outcomes.
- To explore neurodevelopmental correlates of fetal motor behavior.
- To enhance the characterization of fetal neurologic integrity.
Main Methods:
- Cine MR imaging used for fetal motor behavior sequences (18 weeks' gestation to term).
- Analysis of general movement sequences using established criteria.
- Expert fetal neuroradiologist assessment of brain MR imaging and postnatal follow-up (up to 4 years).
Main Results:
- Fetuses with normal brain MR imaging predominantly showed normal general movements (19/21).
- Fetuses with abnormal brain MR imaging showed a significant relationship between malformation severity and postnatal outcome (P = .021).
- A significant correlation was found between neurodevelopmental outcome, general movement quality, and fetal brain MR imaging (P = .020).
Conclusions:
- Combined structural and functional fetal imaging improves characterization of early neurologic integrity.
- This approach has the potential to inform postnatal outcomes.
- Establishes a foundation for advanced in vivo research in fetal neurodevelopment.
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