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Updated: Feb 9, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
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Memantine induces manic episode in a 73-year-old patient with vascular neurocognitive disorder: a case report

Jinfeng Duan1,2, Chengming Lao3,4, Jingkai Chen1,2

  • 1Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, People's Republic of China.

Neuropsychiatric Disease and Treatment
|June 9, 2018
PubMed

Insights

Memantine, an N-methyl-d-aspartate receptor antagonist, is used for Alzheimer's disease. A case study shows memantine may induce manic episodes in patients with vascular neurocognitive disorder.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Memantine is an NMDA receptor antagonist approved for Alzheimer's disease.
  • Emerging evidence suggests potential efficacy in affective disorders.
  • Common side effects include confusion, dizziness, and agitation.

Observation:

  • A 73-year-old female patient with vascular neurocognitive disorder was treated with memantine.
  • The patient developed a manic episode during memantine treatment.

Findings:

  • This case report details a rare adverse event associated with memantine.
  • The patient's manic episode occurred after initiating memantine therapy.

Implications:

  • Clinicians should be aware of the potential for memantine to induce mania.
  • Further research is needed to understand the neuropsychiatric effects of memantine.
  • This case highlights the importance of monitoring for mood changes in patients receiving memantine.
Keywords:
dementiadepressionmanic episodememantine

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