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Knockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion

Shudong Gu1, Haibin Liang2, Donghui Qi3

  • 1Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226001, China.

Oncotargets and Therapy
|June 9, 2018
PubMed
Abstract

Insights

Kinesin family member 26B (KIF26B) inhibition suppressed breast cancer cell growth, migration, and invasion. Knockdown promoted apoptosis and cell cycle arrest, suggesting KIF26B as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Kinesin family member 26B (KIF26B) is implicated in various human cancers.
  • The specific role of KIF26B in breast cancer remains unclear.

Purpose of the Study:

  • To investigate the function and mechanisms of KIF26B in breast cancer cells.
  • To assess the potential of KIF26B as a therapeutic target.

Main Methods:

  • KIF26B expression was inhibited in MDA-MB-231 and MCF-7 breast cancer cell lines using lentivirus-delivered shRNA.
  • Cell proliferation, colony formation, migration, invasion, cell cycle, and apoptosis were analyzed.

Main Results:

  • KIF26B knockdown significantly inhibited cell proliferation, colony formation, migration, and invasion.
  • KIF26B inhibition led to increased G0/G1 phase cell cycle arrest.
  • KIF26B knockdown promoted apoptosis, evidenced by increased cleaved caspase-3 and Bax expression.

Conclusions:

  • KIF26B plays a critical role in breast cancer tumor growth and metastasis.
  • KIF26B represents a potential therapeutic target for breast cancer treatment.
Keywords:
KIF26Bbreast cancer cellinvasionmigrationproliferation

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