Related Experiment Video
Updated: Feb 9, 2026
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
Published on: June 4, 2012
Early results for active infective endocarditis
Mahdi Aithoussa1,2, Noureddine Atmani1,2, Reda Mounir1,2
1Department of Cardiovascular Surgery, Mohammed V Teaching Military Hospital, Hay Riad, 10100 Rabat, Morocco.
Insights
Early cardiac surgery for infective endocarditis (IE) can lead to good long-term survival, despite high in-hospital mortality. Key risk factors for death include heart failure and renal issues.
Area of Science:
- Cardiology
- Cardiac Surgery
- Infective Endocarditis Research
Background:
- Infective endocarditis (IE) often necessitates urgent cardiac surgery.
- Understanding outcomes and risk factors is crucial for patient management.
Purpose of the Study:
- To analyze immediate and late outcomes of cardiac surgery during active IE.
- To identify predictors of mortality in these patients.
Main Methods:
- Retrospective review of 101 patients undergoing surgery for active IE.
- Analysis of in-hospital and long-term survival data.
- Multivariate analysis to determine risk factors for death.
Main Results:
- In-hospital mortality was 17.9%.
- Predictors of death included congestive heart failure, renal insufficiency, high Euroscore, prolonged cardiopulmonary bypass, and long ICU stay.
- Five-year and ten-year survival rates for surgical survivors were 97% and 91%, respectively.
Conclusions:
- Early surgical intervention in active IE can yield favorable long-term outcomes.
- Despite significant in-hospital risks, timely surgery improves survival.
Introduction:
Cardiac surgery is frequently needed during active phase of infective endocarditis (IE). The purpose of this study was to analyze the immediate and late results and determine the risk factors for death.
Methods:
We retrospectively reviewed 101 patients with IE operated in the active phase. The mean age was 40.5 ± 12.5 years. 16 patients (15.8%) were diagnosed with prosthetic valve endocarditis (PVE). 81 (80.9%) were in NYHA functional class III-IV. Blood cultures were positive in only 24 cases (23.9%).
Results:
in-hospital mortality rate was 17.9% (18 cases). Multivariate analysis indentified five determinant predictor factors: congestive heart failure (CHF), renal insufficiency, high Euroscore, prolonged cardiopulmonary bypass time (> 120 min) and long ICU stay. The median follow-up period was 4.2 (2-6.5) years. Overall survival rate for all patients who survived surgery was 97% at 5 years and 91% at 10 years.
Conclusion:
Despite high in-hospital mortality rate, when patients receive operation early in the active phase of their illness, late outcome may be good.
More Related Videos
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
01:25Endocarditis I: Introduction
01:18Endocarditis III: Medical Management
01:29Endocarditis IV: Nursing Management
01:20Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
01:26Stages of Infection