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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
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Self-Evaluation: Self-Enhancement and Self-Verification03:00

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Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
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Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

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Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
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Raman Spectroscopy Instrumentation: Overview01:26

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Related Experiment Video

Updated: Feb 9, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Surface-enhanced Raman nanoparticles for tumor theranostics applications.

Yangyang Li1,2, Qiaolin Wei1,2, Fei Ma1,2

  • 1Department of Nuclear Medicine & Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Acta Pharmaceutica Sinica. B
|June 9, 2018
PubMed
Summary

Surface-enhanced Raman scattering (SERS) nanoparticles offer advanced in vivo imaging for tumor theranostics and biosensing. Future breakthroughs focus on biocompatible SERS nanoparticles for clinical applications.

Keywords:
Cancer imagingNanoparticlesRaman spectroscopySERSTheranostics

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Area of Science:

  • Biomedical Optics
  • Nanotechnology
  • Spectroscopy

Background:

  • Raman spectroscopy offers molecular specificity and sensitivity for in vivo imaging.
  • Surface-enhanced Raman scattering (SERS) nanoparticles amplify Raman signals.
  • Existing SERS nanoparticles have limitations for clinical translation.

Purpose of the Study:

  • To describe the basis, composition, and methodologies of SERS nanoparticles.
  • To highlight research hotspots in tumor imaging-guided theranostics and biosensing.
  • To identify future directions for clinical applications of SERS technology.

Main Methods:

  • Review of SERS nanoparticle synthesis and characterization.
  • Analysis of SERS applications in tumor theranostics.
  • Evaluation of SERS for biosensing applications.

Main Results:

  • SERS nanoparticles provide high molecular specificity, sensitivity, and low autofluorescence for in vivo imaging.
  • Current research focuses on theranostics and biosensing applications of SERS.
  • Significant advancements have been made in SERS nanoparticle design and application.

Conclusions:

  • SERS nanoparticles are a promising tool for in vivo imaging, theranostics, and biosensing.
  • Further development of biocompatible SERS nanoparticles is crucial.
  • Advancements in spectroscopic devices are needed for clinical translation.