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An Update From the Pediatric Proton Consortium Registry
Clayton B Hess1, Daniel J Indelicato2, Arnold C Paulino3
1Massachusetts General Hospital, Department of Radiation Oncology, Harvard University, Boston, MA, United States.
Frontiers in Oncology
|June 9, 2018
Summary
The Pediatric Proton Consortium Registry (PPCR) now includes over 1,800 children treated with proton therapy, enabling crucial pediatric cancer outcomes research. This valuable data resource supports ongoing and future clinical studies for improved patient care.
Area of Science:
- Pediatric Oncology
- Radiation Oncology
- Clinical Research
Background:
- The Pediatric Proton Consortium Registry (PPCR) was established to facilitate outcomes research for pediatric patients receiving radiotherapy.
- Proton therapy offers a targeted approach to radiation, minimizing exposure to healthy tissues in children.
Purpose of the Study:
- To introduce the PPCR as a comprehensive data resource for the oncology community.
- To provide an overview of the available data for collaboration and further investigation into pediatric proton therapy outcomes.
Main Methods:
- A multi-institutional registry collecting integrated clinical, dosimetric, radiographic, and patient-reported data was established in 2010.
- Enrollment began in 2012, with 13 institutions participating by 2017, collecting data on patient demographics, diagnoses, treatment details, and quality of life.
Main Results:
- The PPCR has enrolled 1,854 pediatric patients from October 2012 to September 2017.
- Central nervous system tumors represent 61% of cases, with medulloblastoma being the most common. Rhabdomyosarcoma is the most frequent non-CNS diagnosis.
- The median follow-up duration is 1.5 years, with a range of 0.14 to 4.6 years.
Conclusions:
- The PPCR has reached a significant milestone, providing a large prospective dataset for pediatric proton therapy outcomes research.
- This registry serves as a vital resource for investigators within the consortium and for external academic research.
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