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Rumen papillomas in sheep.

M Norval, J R Michie, M V Apps

    Veterinary Microbiology
    |April 1, 1985
    PubMed
    Summary
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    Sheep rumen papillomas were studied, with 25 of 200 samples showing lesions. Virus particles were not detected, suggesting low viral presence in these ovine papillomas.

    Area of Science:

    • Veterinary Pathology
    • Ovine Diseases
    • Gastrointestinal Neoplasia

    Background:

    • Papillomas are observed in sheep rumens.
    • The etiology of these rumen papillomas is not fully understood.
    • Comparison with ovine skin warts suggests potential viral involvement.

    Purpose of the Study:

    • To investigate the presence of papillomaviruses in sheep rumen papillomas.
    • To characterize the histological and ultrastructural features of these lesions.
    • To determine the viral etiology of ovine rumen papillomas.

    Main Methods:

    • Examination of 200 sheep rumens from Edinburgh.
    • Histopathological analysis of fibro-papillomatous lesions.
    • Electron microscopy for virus particle identification.

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  • Molecular methods to detect viral DNA.
  • Immunoperoxidase staining for viral antigens.

    • Main Results:

    • Papillomas were found in 25 out of 200 sheep rumens.
    • No viral inclusion bodies or particles were identified by electron microscopy.
    • Viral DNA was not detected in the papillomatous tissue.
    • Immunoperoxidase staining showed a limited presence of positive cells in 6/10 lesions.
    • Lesions were characterized as fibro-papillomas, often multiple, located along the rumen pillar.

    Conclusions:

    • Rumen papillomas in sheep likely have a low viral particle load.
    • Virus particles may be present in few epithelial cells, which are rapidly shed.
    • The findings differ from ovine skin warts, suggesting a distinct pathogenesis or detection challenge.