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Distribution and Functional Implication of Secretin in Multiple Brain Regions
Ruanna Wang1, Billy K C Chow2, Li Zhang3
1Joint International Research Laboratory of CNS Regeneration, GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China.
Journal of Molecular Neuroscience : MN
|June 9, 2018
Summary
Secretin, a hormone known for gut functions, is also found in the brain, influencing behaviors like eating, emotion, and memory. This review explores its neurological roles and therapeutic potential for brain disorders.
Area of Science:
- Neuroscience
- Endocrinology
- Gastroenterology
Background:
- Secretin is a polypeptide hormone traditionally recognized for its gastrointestinal roles.
- Recent findings reveal widespread expression of secretin and its receptor in diverse brain regions, including the cortex, hippocampus, hypothalamus, and cerebellum.
Purpose of the Study:
- To review the region-specific expression of secretin and its receptor within the brain.
- To summarize the central physiological and neurological functions regulated by secretin.
- To discuss the potential of secretin as a therapeutic agent for neurological disorders.
Main Methods:
- Literature review of studies investigating secretin's expression and function in the central nervous system.
- Analysis of research employing genetic manipulation and pharmaceutical interventions to study secretin's neurological effects.
Main Results:
- Secretin and its receptor are expressed in various brain areas, suggesting novel central functions.
- Secretin modulates fundamental behaviors such as water and food intake.
- Emerging evidence links secretin to complex neurological processes including emotion, motor control, and learning/memory.
Conclusions:
- Secretin plays significant roles in the central nervous system, extending beyond its known gastrointestinal functions.
- Further research into secretin's neurological mechanisms is warranted.
- Secretin or its analogs hold promise for the treatment of various neurological conditions.
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