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The importance of 15-lipoxygenase inhibitors in cancer treatment

Ala Orafaie1, Maryam Moghaddam Matin1,2, Hamid Sadeghian3,4

  • 1Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Cancer Metastasis Reviews
|June 9, 2018
PubMed

Insights

15-Lipoxygenase (15-LOX) inhibitors show promise as novel cancer therapeutics. This review explores their anticancer activities, suggesting potential as future chemotherapy agents.

Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • Cancer-targeted therapy, particularly small molecule inhibitors, is a growing field.
  • 15-Lipoxygenase (15-LOX) produces metabolites linked to cancer progression.
  • 15-LOX-1 specifically plays a role in the development of certain cancers.

Purpose of the Study:

  • To review existing literature on 15-Lipoxygenase (15-LOX) inhibitors.
  • To focus on the anticancer activities of these inhibitors.
  • To explore their potential as future cancer therapeutics.

Main Methods:

  • Literature review of publications on 15-LOX inhibitors.
  • Analysis of studies reporting in vitro anticancer activities.
  • Evaluation of studies reporting in vivo anticancer activities.

Main Results:

  • Numerous 15-LOX inhibitors have been identified.
  • Separate studies demonstrate anticancer effects for many reported inhibitors.
  • Evidence suggests 15-LOX inhibition impacts cancer cell proliferation.

Conclusions:

  • 15-LOX inhibitors represent a promising area for novel cancer therapeutics.
  • These inhibitors may serve as effective chemotherapy agents in the future.
  • Further research into the mechanisms of antiproliferative effects is warranted.
Keywords:
15-LOXAzineCannabidiolCatecholCoumarinFlavonoid

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