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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
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Coagulase-Negative Staphylococcus Skin and Soft Tissue Infections
Nicola E Natsis1, Philip R Cohen2
1University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA, 92093, USA. nnatsis@ucsd.edu.
American Journal of Clinical Dermatology
|June 9, 2018
Summary
Coagulase-negative staphylococci, often skin flora, can cause serious skin and soft tissue infections, particularly in immunocompromised individuals. These infections, commonly abscesses and paronychia, are usually treatable with antibiotics.
Area of Science:
- Microbiology
- Dermatology
- Infectious Diseases
Background:
- Coagulase-negative staphylococci (CoNS) are typically normal skin flora.
- However, CoNS can act as opportunistic pathogens causing various infections.
- Skin and soft tissue infections (SSTIs) are a significant concern in clinical settings.
Purpose of the Study:
- To review the literature on SSTIs caused by CoNS species.
- To identify the common CoNS species involved in SSTIs.
- To characterize the clinical presentation and treatment of CoNS-induced SSTIs.
Main Methods:
- A comprehensive PubMed database search was conducted.
- Keywords included various CoNS species, infection types, and related terms.
- Relevant articles and their references were reviewed.
Main Results:
- Multiple CoNS species, including S. epidermidis, S. haemolyticus, and S. lugdunensis, were identified as causative agents of SSTIs.
- Predominant presentations of CoNS SSTIs are abscesses and paronychia.
- These infections are more prevalent in elderly or immunosuppressed patients.
- CoNS infections generally show broad susceptibility to antibiotics.
Conclusions:
- CoNS should be recognized as potential pathogens in SSTIs, not just contaminants.
- SSTIs caused by CoNS are more common in vulnerable populations.
- Antibiotic susceptibility is generally favorable, similar to methicillin-sensitive Staphylococcus aureus.
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