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Updated: Feb 9, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
A Peptide-Based Supramolecular Hydrogel for Controlled Delivery of Amine Drugs
Youzhi Wang1,2, Yiming Zhang2, Xinxin Li2
1State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300071, P. R. China.
Abstract:
Supramolecular hydrogels hold great promise for controlled drug delivery. Herein we report a supramolecular hydrogel based on a peptide bearing a terminal aldehyde. The hydrogel was prepared via an enzyme instructed self-assembly (EISA) process, and the resulting hydrogels showed ultra-stable properties in highly acidic or basic aqueous solutions. The hydrogelator could form Schiff bases with amine drugs. Owing to the pH-responsive properties of Schiff bases, the hydrogels could be used for controlled release of encapsulated amine drugs. Our study provides a peptide-based hydrogel that may be applied for controlled drug delivery.
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