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Updated: Feb 9, 2026

Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
Streptococcus sanguinis biofilm formation & interaction with oral pathogens
Bin Zhu1, Lorna C Macleod1, Todd Kitten1,2
1Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA 23298, USA.
Abstract:
Caries and periodontitis are the two most common human dental diseases and are caused by dysbiosis of oral flora. Although commensal microorganisms have been demonstrated to protect against pathogens and promote oral health, most previous studies have addressed pathogenesis rather than commensalism. Streptococcus sanguinis is a commensal bacterium that is abundant in the oral biofilm and whose presence is correlated with health. Here, we focus on the mechanism of biofilm formation in S. sanguinis and the interaction of S. sanguinis with caries- and periodontitis-associated pathogens. In addition, since S. sanguinis is well known as a cause of infective endocarditis, we discuss the relationship between S. sanguinis biofilm formation and its pathogenicity in endocarditis.
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