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Spotlight on avian pathology: Marek's disease
1a Viral Oncogenesis Group & OIE Marek's Disease Virus Reference Laboratory , Pirbright Institute , Surrey , UK.
Avian Pathology : Journal of the W.V.P.A
|June 9, 2018
Summary
Marek's disease (MD) is a major poultry pathogen controlled by vaccination and genetic resistance. However, evolving virus virulence and new hypervirulent strains pose ongoing challenges for sustainable disease management.
Area of Science:
- Poultry Health
- Veterinary Virology
- Animal Immunology
Background:
- Marek's disease (MD) is a significant global poultry disease.
- It causes lymphoid tumors, immunosuppression, and paralysis.
- Economic losses in the poultry industry are substantial.
Purpose of the Study:
- To review the current strategies for controlling Marek's disease.
- To highlight the challenges posed by the evolving virulence of Marek's disease virus (MDV).
- To discuss the need for sustainable control measures.
Main Methods:
- Review of existing literature on Marek's disease.
- Analysis of vaccination policies and genetic resistance strategies.
- Examination of Marek's disease virus (MDV) evolution and pathotypes.
Main Results:
- Vaccination with live attenuated vaccines is the primary control method.
- Genetic resistance has contributed to MD control.
- Emergence of hypervirulent MDV pathotypes presents a significant challenge.
Conclusions:
- Current control strategies have been largely successful but face challenges.
- Continuous evolution of MDV virulence requires adaptive control measures.
- Sustainable control necessitates ongoing research and integrated approaches.