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SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity

Sonia Alonso-Martin1,2,3, Frédéric Auradé4, Despoina Mademtzoglou1,2,3

  • 1Institut Mondor de Recherche Biomédicale, INSERM U955-E10, Créteil, France.

Elife
|June 9, 2018
PubMed

Insights

SoxF transcriptional factors are crucial for muscle stem cell function, regulating their self-renewal and differentiation. Their activity is essential for muscle growth and regeneration, interacting with Wnt/β-catenin signaling.

Area of Science:

  • Muscle stem cell biology
  • Transcriptional regulation
  • Skeletal muscle regeneration

Background:

  • Muscle satellite cells are stem cells vital for muscle growth and repair.
  • Genetic control of satellite cell function is under active investigation.
  • SOXF (SOX7, SOX17, SOX18) transcriptional factors are induced during satellite cell specification.

Purpose of the Study:

  • To investigate the role of SOXF transcriptional factors in muscle stem cell regulation.
  • To determine the impact of SOXF genes on muscle growth and regeneration.
  • To elucidate the molecular mechanisms by which SOXF factors control satellite cell behavior.

Main Methods:

  • Analysis of SOXF factor induction during satellite cell specification.
  • Assessment of SOXF factor roles in satellite cell quiescence, self-renewal, and differentiation.
  • Gene ablation studies (Sox17) in the muscle lineage.
  • Investigation of SOXF factor overlap and transcriptional activity in muscle regeneration.
  • Examination of SOXF factor interaction with Wnt/β-catenin signaling pathways.

Main Results:

  • SOXF factors regulate satellite cell quiescence, self-renewal, and differentiation.
  • Sox17 ablation impairs postnatal muscle growth and regeneration.
  • SOXF factors exhibit overlapping functions in muscle regeneration, requiring SOXF transcriptional activity.
  • SOXF factors directly inhibit Wnt/β-catenin signaling output, including Ccnd1 and Axin2.

Conclusions:

  • SOXF genes play a key regulatory role in muscle stem cells.
  • SOXF factors control satellite cell function through direct transcriptional control.
  • SOXF factors interact with canonical Wnt/β-catenin signaling to modulate muscle stem cell activity.
Keywords:
SoxFadult stem cellsdevelopmental biologymouseregenerative medicinesatellite cellsself-renewalskeletal muscle regenerationstem cellsß-catenin

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